Csf2rb^tm1Cgb
Targeted Allele Detail

Summary

• Symbol: Csf2rb^tm1Cgb
• Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); targeted mutation 1, C Glenn Begley
• MGI ID: MGI:2181245
• Synonyms: Beta-c^-, Betac^-, GM-CSFR^-
• Gene: Csf2rb Location: Chr15:78210000-78235201 bp, + strand Genetic Position: Chr15, 37.36 cM
• Alliance: Csf2rb^tm1Cgb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29737
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 7 was disrupted by the insertion of a neomycin selection cassette that introduced stop codons into all three reading frames. A binding assay of homozygous bone marrow cells showed that high affinity binding of the colony stimulating factor was ablated. Binding of interleukin 3 was unaffected in cells isolated from mutant mice, indicating that the homologous interleukin 3 receptor was not affected by the targeting event. (J:29737)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Csf2rb Mutation: 47 strains or lines available

References

• Original: J:29737 Robb L, et al., Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9565-9
• All: 55 reference(s)