Csf2rb^tm1Mur
Targeted Allele Detail

Summary

• Symbol: Csf2rb^tm1Mur
• Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); targeted mutation 1, Richard Murray
• MGI ID: MGI:2181261
• Synonyms: betac^-, betac mutant
• Gene: Csf2rb Location: Chr15:78210000-78235201 bp, + strand Genetic Position: Chr15, 37.36 cM
• Alliance: Csf2rb^tm1Mur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24122
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced by a neomycin cassette via homologous recombination. The deleted region encodes the third and fourth cysteine residues in the first repeat of the conserved motif of cytokine receptors. FACS analysis of bone marrow cells isolated from homozygous mutant mice showed a lack of a functional receptor. Additional FACS analysis showed that expression of the homologous protein, Csf3rb2, was intact. (J:24122)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csf2rb Mutation: 47 strains or lines available

References

• Original: J:24122 Nishinakamura R, et al., Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal. Immunity. 1995 Mar;2(3):211-22
• All: 7 reference(s)