Arl4a^tm1Asch
Targeted Allele Detail

Summary

• Symbol: Arl4a^tm1Asch
• Name: ADP-ribosylation factor-like 4A; targeted mutation 1, A Schurmann
• MGI ID: MGI:2181269
• Synonyms: Arl4^-
• Gene: Arl4a Location: Chr12:40083290-40087986 bp, - strand Genetic Position: Chr12, 18.06 cM
• Alliance: Arl4a^tm1Asch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75778
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 of the gene was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis confirmed the absence of mRNA transcripts from testis, spleen, and intestine of homozygous mutant animals, and immunohistochemical analysis of testes sections demonstrated the absence of protein product. (J:75778)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arl4a Mutation: 7 strains or lines available

References

• Original: J:75778 Schurmann A, et al., Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene. Mol Cell Biol. 2002 Apr;22(8):2761-8
• All: 2 reference(s)