Csf2rb2^tm1Mur
Targeted Allele Detail

Summary

• Symbol: Csf2rb2^tm1Mur
• Name: colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage); targeted mutation 1, Richard Murray
• MGI ID: MGI:2181272
• Synonyms: betail3^-
• Gene: Csf2rb2 Location: Chr15:78166707-78189921 bp, - strand Genetic Position: Chr15, 37.22 cM
• Alliance: Csf2rb2^tm1Mur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24122
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a neomycin cassette via homologous recombination. The deleted region encodes the third and fourth cysteine residues in the first repeat of the conserved motif of cytokine receptors. The encoded protein was undetected by Western blot analysis of extracts from mast-cells isolated from homozygous mutant mice. FACS analysis showed that the homologous protein, Csf2rb1, was expressed. (J:24122)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csf2rb2 Mutation: 47 strains or lines available

References

• Original: J:24122 Nishinakamura R, et al., Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal. Immunity. 1995 Mar;2(3):211-22
• All: 1 reference(s)