Gpd2^tm1Tka
Targeted Allele Detail

Summary

• Symbol: Gpd2^tm1Tka
• Name: glycerol phosphate dehydrogenase 2, mitochondrial; targeted mutation 1, Takashi Kadowaki
• MGI ID: MGI:2181289
• Synonyms: mGPDH-
• Gene: Gpd2 Location: Chr2:57127690-57260731 bp, + strand Genetic Position: Chr2, 31.66 cM
• Alliance: Gpd2^tm1Tka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75839
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 5 via homologous recombination. The absence of protein expression was verified by Western blot and enzyme assay of islet samples from homozygous mutant animals. (J:75839)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpd2 Mutation: 85 strains or lines available

References

• Original: J:75839 Eto K, et al., Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science. 1999 Feb 12;283(5404):981-5
• All: 14 reference(s)