Cd44^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Cd44^tm1Mak
• Name: CD44 antigen; targeted mutation 1, Tak W Mak
• MGI ID: MGI:2181292
• Synonyms: CD44-
• Gene: Cd44 Location: Chr2:102641486-102732010 bp, - strand Genetic Position: Chr2, 54.13 cM
• Alliance: Cd44^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72658
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' portion of exon 2 and all of exon 3 were replaced by the insertion of a neomycin resistance cassette. The deleted region encodes part of the invariant amino terminus, common to all isoforms. A lack of protein surface expression was observed in spleen, lymph node, and thymus cells via flow cytometry. (J:72658)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd44 Mutation: 72 strains or lines available

References

• Original: J:72658 Schmits R, et al., CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood. 1997 Sep 15;90(6):2217-33
• All: 77 reference(s)