Hp^tm1Skl
Targeted Allele Detail

Summary

• Symbol: Hp^tm1Skl
• Name: haptoglobin; targeted mutation 1, Sai-Kiang Lim
• MGI ID: MGI:2181293
• Synonyms: Hp^-, Hp 0
• Gene: Hp Location: Chr8:110301760-110305804 bp, - strand Genetic Position: Chr8, 57.11 cM
• Alliance: Hp^tm1Skl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49888
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-4 were replaced with a neomycin resistance gene via homologous recombination. RT-PCR analysis of liver and Western blot analysis of plasma from homozygous mutant animals verified the absence of gene expression from the null allele. (J:49888)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hp Mutation: 13 strains or lines available

References

• Original: J:49888 Lim SK, et al., Increased susceptibility in Hp knockout mice during acute hemolysis. Blood. 1998 Sep 15;92(6):1870-7
• All: 23 reference(s)