Ppp3cb^tm1Jmk
Targeted Allele Detail

Summary

• Symbol: Ppp3cb^tm1Jmk
• Name: protein phosphatase 3, catalytic subunit, beta isoform; targeted mutation 1, Jeffery D Molkentin
• MGI ID: MGI:2181294
• Synonyms: Abeta-, Cnab^-, CnAbeta-, CnAbeta KO
• Gene: Ppp3cb Location: Chr14:20549432-20596641 bp, - strand Genetic Position: Chr14, 11.53 cM, cytoband B
• Alliance: Ppp3cb^tm1Jmk page

Cardiac histological analysis of wild type and Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75775
• Parent Cell Line: KG-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the catalytic domain of the protein was replaced with a neomycin resistance cassette via homologous recombination. Western blot analysis confirmed the absence of gene expression in brain of homozygous mutant animals. (J:75775)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppp3cb Mutation: 67 strains or lines available

References

• Original: J:75775 Bueno OF, et al., Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4586-91
• All: 34 reference(s)