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Jph3tm1Hta
Targeted Allele Detail
Summary
Symbol: Jph3tm1Hta
Name: junctophilin 3; targeted mutation 1, Hiroshi Takeshima
MGI ID: MGI:2181318
Synonyms: JP-3(-)
Gene: Jph3  Location: Chr8:122457298-122517822 bp, + strand  Genetic Position: Chr8, 70.73 cM, cytoband E1
Alliance: Jph3tm1Hta page
Irregular hindlimb reflex in Jph3tm1Hta/Jph3tm1Hta Jph4tm1Hta/Jph4tm1Hta mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75794
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Western blot of brain verified the absence of protein product in homozygous mutant mice. Northern blot showed no compensatory expression from Jph1 or Jph2 in the brain of homozygous mutant mice. (J:75794)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jph3 Mutation:  30 strains or lines available
References
Original:  J:75794 Nishi M, et al., Motor discoordination in mutant mice lacking junctophilin type 3. Biochem Biophys Res Commun. 2002 Mar 29;292(2):318-24
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory