Pdx1^tm1Cvw
Targeted Allele Detail

Summary

• Symbol: Pdx1^tm1Cvw
• Name: pancreatic and duodenal homeobox 1; targeted mutation 1, Christopher VE Wright
• MGI ID: MGI:2181360
• Synonyms: Ipf1^-, pdx-1 -, pdx^XBko-
• Gene: Pdx1 Location: Chr5:147206907-147212658 bp, + strand Genetic Position: Chr5, 86.84 cM
• Alliance: Pdx1^tm1Cvw page

Pancreatic hypoplasia in Pdx1^tm1Cvw/Pdx1^tm1.1Stof mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32017
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 2 with a neomycin resistance cassette resulting in the deletion of the DNA-binding homeodomain. Immunostaining of E9.5 embryos with antibodies directed against the N-terminus of the protein did not detect protein product. (J:32017)

Disease models

Expression

In Mice Carrying this Mutation:	19 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdx1 Mutation: 35 strains or lines available

References

• Original: J:32017 Offield MF, et al., PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996 Mar;122(3):983-95
• All: 19 reference(s)