Itgal^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Itgal^tm1Mak
• Name: integrin alpha L; targeted mutation 1, Tak W Mak
• MGI ID: MGI:2181378
• Synonyms: CD11a -, LFA-1^-
• Gene: Itgal Location: Chr7:126895432-126934310 bp, + strand Genetic Position: Chr7, 69.44 cM
• Alliance: Itgal^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77269
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding the signal peptide and the amino terminal extracellular domain (exons 2 through 6) was replaced with a neomycin selection cassette. Surface expression was undetected by FACS analysis of homozygous mutant B and T cells. (J:77269)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Itgal Mutation: 76 strains or lines available

References

• Original: J:77269 Schmits R, et al., LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J Exp Med. 1996 Apr 1;183(4):1415-26
• All: 20 reference(s)