Creb1^tm2Gsc
Targeted Allele Detail

Summary

• Symbol: Creb1^tm2Gsc
• Name: cAMP responsive element binding protein 1; targeted mutation 2, Gunther Schutz
• MGI ID: MGI:2181382
• Synonyms: CREB -
• Gene: Creb1 Location: Chr1:64571963-64643707 bp, + strand Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
• Alliance: Creb1^tm2Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47431
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A promoterless neomycin resistance gene was inserted in frame into exon 10, and all of intron 10 and part of exon 11 were deleted. The deleted sequences encode part of the DNA binding domain and the leucine zipper domain. RT-PCR analysis on total brain RNA demonstrated that no transcripts containing the 3' end were detectable; however, a fusion transcript containing the lacZ sequences is detected. (J:47431)

Expression

In Mice Carrying this Mutation:

39 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Creb1 Mutation: 61 strains or lines available

References

• Original: J:47431 Rudolph D, et al., Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4481-6
• All: 7 reference(s)