Hnf1b^tm2Mya
Targeted Allele Detail

Summary

• Symbol: Hnf1b^tm2Mya
• Name: HNF1 homeobox B; targeted mutation 2, Moshe Yaniv
• MGI ID: MGI:2181390
• Synonyms: Hnf1beta^del, vHNF1/del
• Gene: Hnf1b Location: Chr11:83741035-83796743 bp, + strand Genetic Position: Chr11, 51.23 cM
• Alliance: Hnf1b^tm2Mya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58080
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin selection cassette and an additional loxP site were inserted at the endogenous locus via homologous recombination. Deletion of the promoter region, the transcription initiation site, and exon 1 was achieved by the transient expression of cre recombinase in ES cells. (J:58080)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnf1b Mutation: 16 strains or lines available

References

• Original: J:58080 Coffinier C, et al., Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation. Development. 1999 Nov;126(21):4785-94
• All: 3 reference(s)