Creb1^tm3Gsc
Targeted Allele Detail

Summary

• Symbol: Creb1^tm3Gsc
• Name: cAMP responsive element binding protein 1; targeted mutation 3, Gunther Schutz
• MGI ID: MGI:2181395
• Synonyms: Creb1^loxP, CREB^fl, Creb^lox
• Gene: Creb1 Location: Chr1:64571963-64643707 bp, + strand Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
• Alliance: Creb1^tm3Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76211
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted 5' to exon 10 and a loxP flanked neomycin and thymidine kinase cassette was inserted 3' to exon 10. Transient transfection of Cre recombinase in ES cells resulted in the deletion of the neomycin and thymidine kinase cassette, leaving single loxP sites flanking exon 10 in the final allele. (J:76211)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Creb1 Mutation: 61 strains or lines available

References

• Original: J:76211 Mantamadiotis T, et al., Disruption of CREB function in brain leads to neurodegeneration. Nat Genet. 2002 May;31(1):47-54
• All: 36 reference(s)