Rpe65^tm1Tmr
Targeted Allele Detail

Summary

• Symbol: Rpe65^tm1Tmr
• Name: retinal pigment epithelium 65; targeted mutation 1, T Michael Redmond
• MGI ID: MGI:2181399
• Synonyms: Rpe65-
• Gene: Rpe65 Location: Chr3:159304812-159330958 bp, + strand Genetic Position: Chr3, 82.52 cM, cytoband H4
• Alliance: Rpe65^tm1Tmr page

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51293
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3 of the gene were replaced with a PGK-neo cassette via homologous recombination. RT-PCR analysis of whole mouse eyes confirmed the null allele in homozygous mutant animals. (J:51293)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rpe65 Mutation: 52 strains or lines available

References

• Original: J:51293 Redmond TM, et al., Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet. 1998 Dec;20(4):344-51
• All: 97 reference(s)