Rbp1^tm1Ipc
Targeted Allele Detail

Summary

• Symbol: Rbp1^tm1Ipc
• Name: retinol binding protein 1, cellular; targeted mutation 1, Pierre Chambon
• MGI ID: MGI:2181412
• Synonyms: CRBPI^-, CRBP-I-KO
• Gene: Rbp1 Location: Chr9:98305014-98328604 bp, + strand Genetic Position: Chr9, 51.36 cM
• Alliance: Rbp1^tm1Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57825
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 2 via homologous recombination. Western blot analysis verified the absence of protein expression in homozygous mutant embryos. (J:57825)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rbp1 Mutation: 10 strains or lines available

References

• Original: J:57825 Ghyselinck NB, et al., Cellular retinol-binding protein I is essential for vitamin A homeostasis. EMBO J. 1999 Sep 15;18(18):4903-14
• All: 16 reference(s)