Pla2g4a^tm1Jvb
Targeted Allele Detail

Summary

• Symbol: Pla2g4a^tm1Jvb
• Name: phospholipase A2, group IVA (cytosolic, calcium-dependent); targeted mutation 1, Joseph V Bonventre
• MGI ID: MGI:2181427
• Synonyms: cPLA2-, cPLA2alpha-, cPLA2-KO, gIVaPLA2^null, Pla2g4a-
• Gene: Pla2g4a Location: Chr1:149705369-149837041 bp, - strand Genetic Position: Chr1, 63.51 cM
• Alliance: Pla2g4a^tm1Jvb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39681
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of sequences encoding amino acids 187-232 with a PGK-neo-polyA cassette via homologous recombination. Protein product was absent in various organ samples from homozygous mutant animals as determined by Western blot analysis. (J:39681)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g4a Mutation: 62 strains or lines available

References

• Original: J:39681 Bonventre JV, et al., Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nature. 1997 Dec 11;390(6660):622-5
• All: 53 reference(s)