Sox2^tm2Skn
Targeted Allele Detail

Summary

• Symbol: Sox2^tm2Skn
• Name: SRY (sex determining region Y)-box 2; targeted mutation 2, Silvia K Nicolis
• MGI ID: MGI:2181440
• Synonyms: allele 2, Sox2^Beta-geo
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^tm2Skn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62026
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced by a construct containing a beta-geo fusion gene, lacking a promoter. Recombination of the construct left the 5' flanking region intact, enabling the expression of the beta-geo transgene to be under the control of the endogenous promoter and regulatory sequences. (J:62026)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:62026 Zappone MV, et al., Sox2 regulatory sequences direct expression of a (beta)-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells. Development. 2000 Jun;127(11):2367-82
• All: 5 reference(s)