Tg(Col2a1-Fgfr3/GH)BDor
Transgene Detail

Summary

• Symbol: Tg(Col2a1-Fgfr3/GH)BDor
• Name: transgene insertion B, David M Ornitz
• MGI ID: MGI:2181547
• Synonyms: FGFR3^ach
• Transgene: Tg(Col2a1-Fgfr3/GH)BDor Location: unknown
• Alliance: Tg(Col2a1-Fgfr3/GH)BDor page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Col2a1-Fgfr3/GH)BDor expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fgfr3 (MGI:95524)

• Mutation details: The transgene consists a mouse cDNA of Fgfr3 which harbors a dominant mutation found in human achondroplasia (G380R). This sequence is fused to human growth hormone gene with a deletion in exon 5 to provide additional splice and polyadenylation sites.Expression of the transgene is targeted to cartilage tissue by promoter and enhancer sequences derived from rat type II collagen gene. (J:50292)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic lines A and B were established and characterized. The phenotype of line A was less severe than that of line B, presumably due to a dosage effect of the transgene.

References

• Original: J:50292 Naski MC, et al., Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development. 1998 Dec;125(24):4977-88
• All: 13 reference(s)