Jchain^tm1Jse
Targeted Allele Detail

Summary

• Symbol: Jchain^tm1Jse
• Name: immunoglobulin joining chain; targeted mutation 1, Jonathan G Seidman
• MGI ID: MGI:2181559
• Synonyms: Jch^-
• Gene: Jchain Location: Chr5:88667663-88675667 bp, - strand Genetic Position: Chr5, 43.7 cM
• Alliance: Jchain^tm1Jse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75843
• Parent Cell Line: C1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 2 via homologous recombination. Homozygous mutant animals lacked gene expression as demonstrated by Northern blot analysis of spleen cells and Western blot analysis of serum. (J:75843)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jchain Mutation: 24 strains or lines available

References

• Original: J:75843 Hendrickson BA, et al., Altered hepatic transport of immunoglobulin A in mice lacking the J chain. J Exp Med. 1995 Dec 1;182(6):1905-11
• All: 5 reference(s)