Akt1^tm1Nhy
Targeted Allele Detail

Summary

• Symbol: Akt1^tm1Nhy
• Name: thymoma viral proto-oncogene 1; targeted mutation 1, Nissim Hay
• MGI ID: MGI:2181580
• Synonyms: Akt1^-, Akt1 KO
• Gene: Akt1 Location: Chr12:112620260-112641266 bp, - strand Genetic Position: Chr12, 61.2 cM, cytoband F1-F2
• Alliance: Akt1^tm1Nhy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71404
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 through 13 were replaced with a neomycin selection cassette. Encoded protein was not detected by Western blot analysis of fibroblasts isolated from homozygous mutant embryos. (J:71404)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Akt1^tm1Nhy

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akt1 Mutation: 34 strains or lines available

References

• Original: J:71404 Chen WS, et al., Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 2001 Sep 1;15(17):2203-8
• All: 31 reference(s)