Stat5b^tm1Hwd
Targeted Allele Detail

Summary

• Symbol: Stat5b^tm1Hwd
• Name: signal transducer and activator of transcription 5B; targeted mutation 1, Helen W Davey
• MGI ID: MGI:2181592
• Synonyms: STAT5b^-, Stat5b KO
• Gene: Stat5b Location: Chr11:100671557-100741407 bp, - strand Genetic Position: Chr11, 63.63 cM
• Alliance: Stat5b^tm1Hwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41784
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into codon 181 via homologous recombination. Absence of gene expression in liver, spleen, mammary gland, thymus, kidney, and skeletal muscle of homozygous mutant animals was demonstrated by Northern and Western blot analyses. (J:41784)

Expression

In Mice Carrying this Mutation:	312108 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stat5b Mutation: 33 strains or lines available

References

• Original: J:41784 Udy GB, et al., Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7239-44
• All: 31 reference(s)