Stat5a^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Stat5a^tm1Jni
• Name: signal transducer and activator of transcription 5A; targeted mutation 1, James N Ihle
• MGI ID: MGI:2181607
• Synonyms: Stat5a-
• Gene: Stat5a Location: Chr11:100750177-100775995 bp, + strand Genetic Position: Chr11, 63.77 cM
• Alliance: Stat5a^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77412
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 2 exons of the gene were replaced with a hygromycin-B resistance cassette via homologous recombination. Immunoprecipitation and Western blot of liver extracts from homozygous mutant animals verified the absence of gene expression. (J:77412)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat5a Mutation: 48 strains or lines available

Notes

ES cell line = E14 (129P2/OlaHsd) or RW4 (129X1/SvJ).

References

• Original: J:77412 Teglund S, et al., Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 1998 May 29;93(5):841-50
• All: 39 reference(s)