Cacna1a^Tg-5J
Spontaneous Allele Detail

Summary

• Symbol: Cacna1a^Tg-5J
• Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; tottering 5 Jackson
• MGI ID: MGI:2181625
• Gene: Cacna1a Location: Chr8:85065268-85366875 bp, + strand Genetic Position: Chr8, 40.95 cM
• Alliance: Cacna1a^Tg-5J page

Mutation origin

• Strain of Origin: B10.M-H2^f/nMob Fmn1^ld-2J/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A G to A substitution at coding cDNA nucleotide 3899 (c.3899G>A) results in a change of arginine codon 1300 to glutamine (p.R1300Q). (J:137816)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacna1a Mutation: 118 strains or lines available

References

• Original: J:137816 Miki T, et al., Two novel alleles of tottering with distinct Ca(v)2.1 calcium channel neuropathologies. Neuroscience. 2008 Jul 31;155(1):31-44
• All: 1 reference(s)