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Smad6tm1Glvn
Targeted Allele Detail
Summary
Symbol: Smad6tm1Glvn
Name: SMAD family member 6; targeted mutation 1, Katherine M Galvin
MGI ID: MGI:2181630
Synonyms: Madh6-
Gene: Smad6  Location: Chr9:63860358-63929341 bp, - strand  Genetic Position: Chr9, 34.4 cM, cytoband D
Alliance: Smad6tm1Glvn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60214
Parent Cell Line:  MPI-12D (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA cassette containing an NLS-lacZ gene adjoined to a neo gene replaced the 5' terminus of the exon encoding the MH2 domain, which has been implicated as the major effector domain. Northern blot analyses of lung tissue detected the lacZ fusion transcript, lacking the targeted MH2 domain, in mutant mice. Comparison of X-gal staining and in situ hybridization results showed that the expression pattern of beta-galactosidase resembled that of the endogenous locus in wild-type mice, with the exception of upregulation in the epi- and endocardial cells of the right atrium in homozygous mutant mice. (J:60214)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 45 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad6 Mutation:  24 strains or lines available
References
Original:  J:60214 Galvin KM, et al., A role for smad6 in development and homeostasis of the cardiovascular system. Nat Genet. 2000 Feb;24(2):171-4
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory