Igf2r^tm1Stw
Targeted Allele Detail

Summary

• Symbol: Igf2r^tm1Stw
• Name: insulin-like growth factor 2 receptor; targeted mutation 1, Colin L Stewart
• MGI ID: MGI:2181634
• Gene: Igf2r Location: Chr17:12901293-12988551 bp, - strand Genetic Position: Chr17, 8.64 cM, cytoband A-C
• Alliance: Igf2r^tm1Stw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22124
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 13-18 with a PGK-neo cassette via homologous recombination. (J:22124)

Expression

In Mice Carrying this Mutation:	67 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf2r Mutation: 99 strains or lines available

Notes

This gene is paternally imprinted and only expressed when maternally inherited. When this allele is inherited maternally mice are equivalent to homozygous knock-out mice and when this allele is inherited paternally mice are equivalent to homozygous wild-type mice.

References

• Original: J:22124 Lau MM, et al., Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev. 1994 Dec 15;8(24):2953-63
• All: 4 reference(s)