Tbpl1^tm1Rgr
Targeted Allele Detail

Summary

• Symbol: Tbpl1^tm1Rgr
• Name: TATA box binding protein-like 1; targeted mutation 1, Robert G Roeder
• MGI ID: MGI:2181639
• Synonyms: Trf2^-
• Gene: Tbpl1 Location: Chr10:22579778-22607837 bp, - strand Genetic Position: Chr10, 10.25 cM, cytoband A3
• Alliance: Tbpl1^tm1Rgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69502
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette deleted exons 3 through 6, encoding approximately 80% of the core region of the protein. Northern blot analysis of total RNA, using a probe corresponding to the targeted region, showed an absence of transcript in the testes of homozygous mutant mice. (J:69502)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbpl1 Mutation: 10 strains or lines available

References

• Original: J:69502 Zhang D, et al., Spermiogenesis deficiency in mice lacking the Trf2 gene. Science. 2001 May 11;292(5519):1153-5
• All: 2 reference(s)