Ireb2^tm1Roua
Targeted Allele Detail

Summary

• Symbol: Ireb2^tm1Roua
• Name: iron responsive element binding protein 2; targeted mutation 1, Tracey Rouault
• MGI ID: MGI:2181660
• Synonyms: Ireb2-, IRP-2-, IRP2-
• Gene: Ireb2 Location: Chr9:54771073-54819814 bp, + strand Genetic Position: Chr9, 29.81 cM
• Alliance: Ireb2^tm1Roua page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67313
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin cassette deleted portions of exon 3 and 4. Northern blot analysis showed the presence of a larger transcript, containing the neomycin gene, in homozygous mutant mice. A lack of Ireb2 protein and normal levels of Ireb1 was determined by Western blot analysis of fibroblast lysates derived from homozygous mutant mice. (J:67313)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ireb2 Mutation: 64 strains or lines available

References

• Original: J:67313 LaVaute T, et al., Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet. 2001 Feb;27(2):209-14
• All: 28 reference(s)