Rom1^tm1Mci
Targeted Allele Detail

Summary

• Symbol: Rom1^tm1Mci
• Name: rod outer segment membrane protein 1; targeted mutation 1, Roderick R McInnes
• MGI ID: MGI:2181662
• Synonyms: Rom1^-
• Gene: Rom1 Location: Chr19:8904755-8906720 bp, - strand Genetic Position: Chr19, 6.03 cM
• Alliance: Rom1^tm1Mci page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61888
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exon 1 and a 5' portion of exon 2. Western blot analysis of crude retinal extracts showed an absence of encoded protein in homozygous mutant mice. (J:61888)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rom1 Mutation: 10 strains or lines available

References

• Original: J:61888 Clarke G, et al., Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis. Nat Genet. 2000 May;25(1):67-73
• All: 7 reference(s)