Ece2^tm1Ywa
Targeted Allele Detail

Summary

• Symbol: Ece2^tm1Ywa
• Name: endothelin converting enzyme 2; targeted mutation 1, Masashi Yanagisawa
• MGI ID: MGI:2181668
• Synonyms: ECE-2^-
• Gene: Ece2 Location: Chr16:20448601-20464665 bp, + strand Genetic Position: Chr16, 12.48 cM, cytoband B1
• Alliance: Ece2^tm1Ywa page

Cardiac defects in Ece1^tm1Reh/Ece1^tm1Reh and Ece1^tm1Reh/Ece1^tm1Reh Ece2^tm1Ywa/Ece2^tm1Ywa embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62261
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 14 and 15, the latter of which encodes the essential conserved zinc-binding motif, were replaced with a neomycin selection cassette. RT-PCR analysis of total RNA extracted from homozygous mutant brain tissue showed an absence of expression. (J:62261)

Disease models

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ece2 Mutation: 29 strains or lines available

References

• Original: J:62261 Yanagisawa H, et al., Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. J Clin Invest. 2000 May;105(10):1373-82
• All: 7 reference(s)