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Cd9tm1Mek
Targeted Allele Detail
Summary
Symbol: Cd9tm1Mek
Name: CD9 antigen; targeted mutation 1, Eisuke Mekada
MGI ID: MGI:2181695
Synonyms: CD9-
Gene: Cd9  Location: Chr6:125437229-125471723 bp, - strand  Genetic Position: Chr6, 59.32 cM
Alliance: Cd9tm1Mek page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59402
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence, encompassing a portion of exon 3 and all of exon 4 and encoding the second and third transmembrane domains, was replaced with a neomycin selection cassette. Flow cytometric analysis showed an absence of encoded protein on the surface of bone marrow cells obtained from homozygous mutant mice. An absence of protein expression on homozygous mutant oocyte plasma membranes was determined via immunofluorescent staining. (J:59402)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd9 Mutation:  104 strains or lines available
References
Original:  J:59402 Miyado K, et al., Requirement of CD9 on the egg plasma membrane for fertilization. Science. 2000 Jan 14;287(5451):321-4
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory