Gdf1^tm1Sjl
Targeted Allele Detail

Summary

• Symbol: Gdf1^tm1Sjl
• Name: growth differentiation factor 1; targeted mutation 1, Se-Jin Lee
• MGI ID: MGI:2181719
• Synonyms: Gdf1^-
• Gene: Gdf1 Location: Chr8:70782467-70784237 bp, + strand Genetic Position: Chr8, 34.15 cM
• Alliance: Gdf1^tm1Sjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60755
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 8 with a neomycin resistance cassette via homologous recombination. Homozygous mutant animals were identified by Southern blot analysis. (J:60755)

Disease models

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gdf1 Mutation: 8 strains or lines available

References

• Original: J:60755 Rankin CT, et al., Regulation of left-right patterning in mice by growth/differentiation factor-1. Nat Genet. 2000 Mar;24(3):262-5
• All: 6 reference(s)