Kif3a^tm1Noh
Targeted Allele Detail

Summary

• Symbol: Kif3a^tm1Noh
• Name: kinesin family member 3A; targeted mutation 1, Nobutaka Hirokawa
• MGI ID: MGI:2181727
• Synonyms: kif3A^-
• Gene: Kif3a Location: Chr11:53458206-53492794 bp, + strand Genetic Position: Chr11, 31.97 cM, cytoband A5-B1
• Alliance: Kif3a^tm1Noh page

Severe developmental abnormalities in Kif3a^tm1Noh/Kif3a^tm1Noh mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55332
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences encoding the anterior half of the P loop were replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant embryos lacked gene expression as demonstrated by Western blot analysis of whole E9.5 embryos. (J:55332)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif3a Mutation: 33 strains or lines available

References

• Original: J:55332 Takeda S, et al., Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. J Cell Biol. 1999 May 17;145(4):825-36
• All: 3 reference(s)