L1cam^tm1Mtei
Targeted Allele Detail

Summary

• Symbol: L1cam^tm1Mtei
• Name: L1 cell adhesion molecule; targeted mutation 1, Ned Mantei
• MGI ID: MGI:2181735
• Synonyms: L1^-
• Gene: L1cam Location: ChrX:72897384-72924843 bp, - strand Genetic Position: ChrX, 37.43 cM, cytoband A6-B
• Alliance: L1cam^tm1Mtei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43838
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 8 was disrupted by the insertion of a construct containing adjacent thymidine kinase and neomycin resistance genes. Low levels of a truncated transcript were detected via Northern blot analysis of total RNA isolated from homozygous mutant brain tissue (data not shown). Western blot analysis of protein extracts from homozygous mutant brain tissue showed an absence of the four isoforms detected in extracts from normal brain tissue, though low levels of a 190kD aberrant transcript were detected. (J:43838)

Disease models

Expression

In Mice Carrying this Mutation:	47 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any L1cam Mutation: 12 strains or lines available

References

• Original: J:43838 Dahme M, et al., Disruption of the mouse L1 gene leads to malformations of the nervous system. Nat Genet. 1997 Nov;17(3):346-9
• All: 24 reference(s)