Foxj1^tm1Bph
Targeted Allele Detail

Summary

• Symbol: Foxj1^tm1Bph
• Name: forkhead box J1; targeted mutation 1, Brian P Hackett
• MGI ID: MGI:2181746
• Synonyms: hfh-4^-
• Gene: Foxj1 Location: Chr11:116221530-116226225 bp, - strand Genetic Position: Chr11, 81.16 cM
• Alliance: Foxj1^tm1Bph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50025
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a PGK-neo cassette via homologous recombination. Lack of gene expression in tissues of homozygous mutant animals was confirmed by Northern blot, RT-PCR and in situ hybridization. (J:50025)

Disease models

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxj1 Mutation: 21 strains or lines available

References

• Original: J:50025 Chen J, et al., Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J Clin Invest. 1998 Sep 15;102(6):1077-82
• All: 4 reference(s)