Nfatc1^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Nfatc1^tm1Mak
• Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1, Tak W Mak
• MGI ID: MGI:2181766
• Synonyms: Nfatc1³
• Gene: Nfatc1 Location: Chr18:80649420-80756286 bp, - strand Genetic Position: Chr18, 53.66 cM, cytoband E4
• Alliance: Nfatc1^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46399
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exon 3, which encodes amino-terminal serine residues that are involved in nuclear localization. A lack of encoded transcript and protein was determined by northern and western blot analyses of homozygous mutant embryos. (J:46399)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfatc1 Mutation: 49 strains or lines available

References

• Original: J:46399 de la Pompa JL, et al., Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum [see comments]. Nature. 1998 Mar 12;392(6672):182-6
• All: 7 reference(s)