Kcnab1^tm1Sva
Targeted Allele Detail

Summary

• Symbol: Kcnab1^tm1Sva
• Name: potassium voltage-gated channel, shaker-related subfamily, beta member 1; targeted mutation 1, Alcino J Silva
• MGI ID: MGI:2181771
• Synonyms: Kvbeta1.1-deficient
• Gene: Kcnab1 Location: Chr3:64856636-65285643 bp, + strand Genetic Position: Chr3, 30.15 cM
• Alliance: Kcnab1^tm1Sva page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51147
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into codon 25 of exon 1 via homologous recombination. Northern and Western blot analysis of brain from homozygous mutant animals confirmed the absence of gene expression. (J:51147)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kcnab1 Mutation: 27 strains or lines available

References

• Original: J:51147 Giese KP, et al., Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning. Learn Mem. 1998 Sep-Oct;5(4-5):257-73
• All: 5 reference(s)