Oprl1^tm1Hta
Targeted Allele Detail

Summary

• Symbol: Oprl1^tm1Hta
• Name: opioid receptor-like 1; targeted mutation 1, Hiroshi Takeshima
• MGI ID: MGI:2181784
• Synonyms: morc^m1, NOP^-, NOP-R-, NOR-, ORL1
• Gene: Oprl1 Location: Chr2:181356809-181362778 bp, + strand Genetic Position: Chr2, 103.74 cM, cytoband H2-4
• Alliance: Oprl1^tm1Hta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39955
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of an exon with a lacZ-neo cassette via homologous recombination. Northern blot analysis of brain from homozygous mutant animals confirmed the absence of gene expression. (J:39955)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oprl1 Mutation: 28 strains or lines available

References

• Original: J:39955 Nishi M, et al., Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor. EMBO J. 1997 Apr 15;16(8):1858-64
• All: 34 reference(s)