Flt4^tm1Ali
Targeted Allele Detail

Summary

• Symbol: Flt4^tm1Ali
• Name: FMS-like tyrosine kinase 4; targeted mutation 1, Kari Alitalo
• MGI ID: MGI:2181789
• Synonyms: VEGFR-3^-, Vegfr3^lacZ, VEGFR-3/LacZ, Vegfr3^lz
• Gene: Flt4 Location: Chr11:49500506-49543566 bp, + strand Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
• Alliance: Flt4^tm1Ali page

Abnormal lymphatic development in Nrp2^tm1Ddg/Nrp2⁺ Flt4^tm1Ali/Flt4⁺ mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50761
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene was inserted in the first coding exon allowing its expression to be controlled by the endogenous transcriptional regulatory sequences. Similarity of the expression patterns of the transgene and the endogenous gene was confirmed by in situ hybridization. An absence of endogenous mRNA was observed via in situ hybridaition of homozygous mutant embryonic sections. (J:50761)

Expression

In Mice Carrying this Mutation:	66 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Flt4 Mutation: 77 strains or lines available

References

• Original: J:50761 Dumont DJ, et al., Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science. 1998 Oct 30;282(5390):946-9
• All: 27 reference(s)