Ryr3^tm1Vso
Targeted Allele Detail

Summary

• Symbol: Ryr3^tm1Vso
• Name: ryanodine receptor 3; targeted mutation 1, Vincenzo Sorrentino
• MGI ID: MGI:2181794
• Synonyms: RyR3^-
• Gene: Ryr3 Location: Chr2:112461700-113047441 bp, - strand Genetic Position: Chr2, 57.2 cM, cytoband E5-F3
• Alliance: Ryr3^tm1Vso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45244
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 was replaced with a neomycin resistance gene via homologous recombination resulting in the deletion of the transmembrane domain containing carboxy terminus of the protein. Western blot analysis of microsomal proteins from diaphram muscles confirmed the absence of gene expression in homozygous mutant animals. (J:45244)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ryr3 Mutation: 261 strains or lines available

References

• Original: J:45244 Bertocchini F, et al., Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles. EMBO J. 1997 Dec 1;16(23):6956-63
• All: 11 reference(s)