Cacnb1^tm1Rgg
Targeted Allele Detail

Summary

• Symbol: Cacnb1^tm1Rgg
• Name: calcium channel, voltage-dependent, beta 1 subunit; targeted mutation 1, Ronald G Gregg
• MGI ID: MGI:2181804
• Synonyms: cchb1^tm1, cchbl^-
• Gene: Cacnb1 Location: Chr11:97892339-97913860 bp, - strand Genetic Position: Chr11, 61.5 cM
• Alliance: Cacnb1^tm1Rgg page

Muscle mass reduction and disorganization of myofibrils in Cacnb1^tm1Rgg/Cacnb1^tm1Rgg mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37052
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exon 6, which is common to all isoforms, and exons 7a and 7b, which are specific to muscle and brain isoforms, respectively. Protein was undetected by immunofluorescence analysis of homozygous mutant myotubes. (J:37052)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacnb1 Mutation: 26 strains or lines available

References

• Original: J:37052 Gregg RG, et al., Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13961-6
• All: 6 reference(s)