Lgals1^tm1Rob
Targeted Allele Detail

Summary

• Symbol: Lgals1^tm1Rob
• Name: lectin, galactose binding, soluble 1; targeted mutation 1, Elizabeth J Robertson
• MGI ID: MGI:2181809
• Synonyms: gal-1^-, gal1^-, Lgals1^-
• Gene: Lgals1 Location: Chr15:78810925-78814665 bp, + strand Genetic Position: Chr15, 37.7 cM, cytoband E
• Alliance: Lgals1^tm1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:16245
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, encoding the carbohydrate-binding domain, was replaced with a neomycin selection cassette. Western blot analysis and immunostaining of sections showed an absence of encoded protein in muscle tissue obtained from adult homozygous mutant mice. (J:16245)

Expression

In Mice Carrying this Mutation:	21 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Lgals1 Mutation: 20 strains or lines available

References

• Original: J:16245 Poirier F, et al., Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin. Development. 1993 Dec;119(4):1229-36
• All: 83 reference(s)