Gja4^tm1Paul
Targeted Allele Detail

Summary

• Symbol: Gja4^tm1Paul
• Name: gap junction protein, alpha 4; targeted mutation 1, David L Paul
• MGI ID: MGI:2181813
• Synonyms: Cx37-
• Gene: Gja4 Location: Chr4:127205214-127207832 bp, - strand Genetic Position: Chr4, 61.47 cM
• Alliance: Gja4^tm1Paul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38247
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region except for the first 77 base pairs was replaced with a PGK-neo cassette. Immunostaining of homozygous mutant oocytes showed a lack of protein expression. (J:38247)

Expression

In Mice Carrying this Mutation:	39 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gja4 Mutation: 15 strains or lines available

References

• Original: J:38247 Simon AM, et al., Female infertility in mice lacking connexin 37. Nature. 1997 Feb 6;385(6616):525-9
• All: 42 reference(s)