Fos^tm1Wag
Targeted Allele Detail

Summary

• Symbol: Fos^tm1Wag
• Name: FBJ osteosarcoma oncogene; targeted mutation 1, Erwin F Wagner
• MGI ID: MGI:2181817
• Synonyms: c-fos^-, fos -
• Gene: Fos Location: Chr12:85520664-85524047 bp, + strand Genetic Position: Chr12, 39.7 cM
• Alliance: Fos^tm1Wag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:3493
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a neomycin selection cassette disrupted exon 2 and introduced a stop codon upstream of codon 54 of the endogeneous gene. (J:3493)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Fos^tm1Wag/Fos^tm1Wag	involves: 129S2/SvPas
hm2	Fos^tm1Wag/Fos^tm1Wag	involves: 129S2/SvPas * C57BL/6
ht3	Fos^tm1Wag/Fos^tm2(Fosl1)Wag	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
cx4	Fos^tm1Wag/Fos^tm1Wag Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6
cx5	Fos^tm1Wag/Fos^tm1Wag Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * C57BL/6

Phenotypes:

Affected Systems	hm1	hm2	ht3	cx4	cx5
show or hide all annotated terms
behavior/neurological	N
behavior/neurological phenotype	N
cellular	√	√	√
increased macrophage apoptosis		√
decreased retina apoptosis	√
increased retina apoptosis			√
craniofacial	√	√	√
craniofacial phenotype	N
failure of tooth eruption	√	√	√
tooth impaction		√
absent teeth		√	√
short snout		√
endocrine/exocrine glands		√
abnormal thymus size		√
decreased thymocyte number		√
growth/size/body	√	√	√
failure of tooth eruption	√	√	√
tooth impaction		√
absent teeth		√	√
short snout		√
decreased body size	√		√
decreased body weight		√
decreased fetal size	√
hematopoietic system	√	√	√
abnormal thymus size		√
decreased thymocyte number		√
decreased double-positive T cell number		√
decreased B cell number		√
increased T cell number		√
decreased osteoclast cell number	√		√
abnormal spleen morphology		√
abnormal spleen white pulp morphology		√
decreased splenocyte number		√
abnormal macrophage physiology		√
increased macrophage apoptosis		√
increased macrophage cytokine production		√
immune system	√	√	√
abnormal thymus size		√
decreased thymocyte number		√
decreased double-positive T cell number		√
decreased B cell number		√
increased T cell number		√
decreased osteoclast cell number	√		√
abnormal spleen morphology		√
abnormal spleen white pulp morphology		√
decreased splenocyte number		√
abnormal macrophage physiology		√
increased macrophage apoptosis		√
increased macrophage cytokine production		√
abnormal cytokine secretion		√
increased susceptibility to bacterial infection		√
limbs/digits/tail		√
short limbs		√
mortality/aging	√
perinatal lethality, incomplete penetrance	√
muscle				√	√
increased rhabdomyosarcoma incidence				√	√
neoplasm				√	√
increased rhabdomyosarcoma incidence				√	√
reproductive system		√
transmission ratio distortion		√
skeleton	√	√	√	√
skeleton phenotype	N
failure of tooth eruption	√	√	√
tooth impaction		√
absent teeth		√	√
decreased osteoclast cell number	√		√
abnormal long bone epiphyseal plate proliferative zone		√
abnormal long bone hypertrophic chondrocyte zone		√
abnormal long bone epiphysis morphology		√
abnormal long bone metaphysis morphology		√
abnormal bone marrow cavity morphology	√	√	√
abnormal compact bone morphology		√
abnormal compact bone thickness		√
increased bone trabecula number		√
osteopetrosis	√	√	√	√
vision/eye	√		√
decreased retina apoptosis	√
increased retina apoptosis			√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fos Mutation: 43 strains or lines available

References

• Original: J:3493 Wang ZQ, et al., Bone and haematopoietic defects in mice lacking c-fos. Nature. 1992 Dec 24-31;360(6406):741-5
• All: 44 reference(s)