Sp1^tm1Phi
Targeted Allele Detail

Summary

• Symbol: Sp1^tm1Phi
• Name: trans-acting transcription factor 1; targeted mutation 1, Sjaak Philipsen
• MGI ID: MGI:2181866
• Synonyms: Sp1^-
• Gene: Sp1 Location: Chr15:102314751-102344839 bp, + strand Genetic Position: Chr15, 57.55 cM
• Alliance: Sp1^tm1Phi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40354
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exons encoding the zinc-finger domains and an essential carboxy terminal region were replaced with a lacZ-neo fusion gene. The lacZ gene was adjoined to a splice acceptor site and IRES, allowing expression and translation of lacZ. (J:40354)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sp1 Mutation: 164 strains or lines available

References

• Original: J:40354 Marin M, et al., Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell. 1997 May 16;89(4):619-28
• All: 5 reference(s)