Ins1^tm1Jja
Targeted Allele Detail

Summary

• Symbol: Ins1^tm1Jja
• Name: insulin I; targeted mutation 1, Jacques Jami
• MGI ID: MGI:2181877
• Synonyms: Ins1^-
• Gene: Ins1 Location: Chr19:52252735-52253453 bp, + strand Genetic Position: Chr19, 46.76 cM
• Alliance: Ins1^tm1Jja page

Growth retardation of Ins1^tm1Jja/Ins1^tm1Jja Ins2^tm1Jja/Ins2^tm1Jja mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40377
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of the coding region was replaced with a neomycin selection cassette. RT-PCR analysis showed an absence of transcript in homozygous mutant mice. (J:40377)

Disease models

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Ins1 Mutation: 46 strains or lines available

References

• Original: J:40377 Duvillie B, et al., Phenotypic alterations in insulin-deficient mutant mice. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5137-40
• All: 36 reference(s)