Ins2^tm1Jja
Targeted Allele Detail

Summary

• Symbol: Ins2^tm1Jja
• Name: insulin II; targeted mutation 1, Jacques Jami
• MGI ID: MGI:2181878
• Synonyms: Ins2-, proins-2-, proinsulin 2-
• Gene: Ins2 Location: Chr7:142232393-142233463 bp, - strand Genetic Position: Chr7, 88.0 cM
• Alliance: Ins2^tm1Jja page

Severe insulitis in Ins2^tm1Jja/Ins2^tm1Jja mice and lack of insulitis in Ins1^tm1Jja/Ins1^tm1Jja mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40377
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of the coding region was replaced by the insertion of a lacZ-neo fusion gene. The expression of lacZ was found to be under the control of the endogenous promoter via cytochemical assays. (J:40377)

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Ins2 Mutation: 93 strains or lines available

References

• Original: J:40377 Duvillie B, et al., Phenotypic alterations in insulin-deficient mutant mice. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5137-40
• All: 46 reference(s)