n-TUtca2^tm1Mmt
Targeted Allele Detail

Summary

• Symbol: n-TUtca2^tm1Mmt
• Name: nuclear encoded tRNA selenocysteine 2 (anticodon TCA); targeted mutation 1, Makoto M Taketo
• MGI ID: MGI:2181883
• Synonyms: Trsp (-)
• Gene: n-TUtca2 Location: Chr7:19035169-19035255 bp, + strand Genetic Position: Chr7, 9.56 cM
• Alliance: n-TUtca2^tm1Mmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40911
• Parent Cell Line: D3a2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire gene was replaced with a neomycin selection cassette inserted by homologous recombination. The levels of tRNA in various organs of heterozygous mice were found to be approximately 50 to 80% of those in wild-type mice. (J:40911)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any n-TUtca2 Mutation: 2 strains or lines available

References

• Original: J:40911 Bosl MR, et al., Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp). Proc Natl Acad Sci U S A. 1997 May 27;94(11):5531-4
• All: 1 reference(s)