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Del(3Cd1d2-Cd1d1)1Crw
Targeted Allele Detail
Summary
Symbol: Del(3Cd1d2-Cd1d1)1Crw
Name: deletion, Chr 3, Chyung-Ru Wang 1
MGI ID: MGI:2181950
Synonyms: CD1-, CD1d-, Cd1d1-, Cd1d1/Cd1d2tm1Crw, CD1d KO, CD1-KO
Gene: Del(3Cd1d2-Cd1d1)1Crw  Location: unknown  Genetic Position: Chr3, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39749
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(3Cd1d2-Cd1d1)1Crw involves 2 genes/genome features (Cd1d2, Cd1d1) View all
 
Mutation detailsCd1d1 and Cd1d2 are adjacent loci that are arranged tail-to-tail, enabling the deletion of exons 4 through 6 from both loci with the insertion of a single neomycin selection cassette. RT-PCR analysis showed an absence of transcript in all tissues tested from homozygous mutant mice. A lack of protein surface expression was determined by immunofluorescence of thymocytes and splenocytes from homozygous mutant animals. (J:39749)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(3Cd1d2-Cd1d1)1Crw Mutation:  0 strains or lines available
References
Original:  J:39749 Chen YH, et al., Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice. Immunity. 1997 Apr;6(4):459-67
All:  79 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory