Del(3Cd1d2-Cd1d1)1Crw
Targeted Allele Detail
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Symbol: |
Del(3Cd1d2-Cd1d1)1Crw |
Name: |
deletion, Chr 3, Chyung-Ru Wang 1 |
MGI ID: |
MGI:2181950 |
Synonyms: |
CD1-, CD1d-, Cd1d1-, Cd1d1/Cd1d2tm1Crw, CD1d KO, CD1-KO |
Gene: |
Del(3Cd1d2-Cd1d1)1Crw Location: unknown Genetic Position: Chr3, Syntenic
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Germline Transmission: |
Earliest citation of germline transmission:
J:39749
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intergenic deletion, Intragenic deletion
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Del(3Cd1d2-Cd1d1)1Crw involves 2 genes/genome features (Cd1d2, Cd1d1)
View all
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Mutation details: Cd1d1 and Cd1d2 are adjacent loci that are arranged tail-to-tail, enabling the deletion of exons 4 through 6 from both loci with the insertion of a single neomycin selection cassette. RT-PCR analysis showed an absence of transcript in all tissues tested from homozygous mutant mice. A lack of protein surface expression was determined by immunofluorescence of thymocytes and splenocytes from homozygous mutant animals.
(J:39749)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Del(3Cd1d2-Cd1d1)1Crw Mutation: |
0 strains or lines available
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Original: |
J:39749 Chen YH, et al., Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice. Immunity. 1997 Apr;6(4):459-67 |
All: |
79 reference(s) |
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