Lhcgr^tm1Zmlei
Targeted Allele Detail

Summary

• Symbol: Lhcgr^tm1Zmlei
• Name: luteinizing hormone/choriogonadotropin receptor; targeted mutation 1, Zhenmin Lei
• MGI ID: MGI:2181998
• Synonyms: LH-, Lhcgr^tm1Cvr, LHRKO
• Gene: Lhcgr Location: Chr17:89023909-89099418 bp, - strand Genetic Position: Chr17, 58.35 cM
• Alliance: Lhcgr^tm1Zmlei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66817
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing promoter elements, multiple transcription start sites and most of exon 1 was replaced by a neomycin selection gene. RT-PCR analysis confirmed that no detectable transcript was present in gonads of homozygous mice. Immunostaining on ovary sections of homozygous mice confirmed that no protein was produced from this allele. (J:66817)

Expression

In Structures Affected by this Mutation:

24 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lhcgr Mutation: 43 strains or lines available

References

• Original: J:66817 Lei ZM, et al., Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene. Mol Endocrinol. 2001 Jan;15(1):184-200
• All: 11 reference(s)